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Dra. Carolina Mascayano

E-mail: 
carolina.mascayano@usach.cl

Biografía: 

La Doctora Carolina Mascayano, realizó sus estudios  el año 2000 para obtener el grado de Licenciado en Química y Químico de  la Universidad de Santiago de Chile.
Posteriormente obtuvo su titulo de Doctor el año 2006 de la misma casa de estudios.

Lineas de Investigación: 

Sus líneas de investigación se enfocan en la Química computacional y médica.

 

Proyectos: 

Entre sus últimos proyectos destacan:

  • 2020-2024       FONDECYT REGULAR    search of new pharmacophores for dual 5-lox and cox-2 inhibitors based on catecholic isoflavan and benzylphenylketone derivatives: biological and in silico complementary approaches (PRINCIPAL)
  • 2019-2022       FONDECYT REGULAR    Organometallic complexes linked to macrocycle groups by a chelating bridging ligand, as potential water-soluble or immobilized sensors for the detection of metal ions CO-INVESTIGADOR
  • 2019-2021       DICYT  Búsqueda de Nuevos Farmacóforos basados en la estructura de bencilfenilcetonas como posibles inhibidores duales de COX-2/5-hLOX: Estudios in-silico y Biológicos.
  • 2017-2020       FONDECYT REGULAR    Enhancement of endothelium signaling by dietary polyphenols and potassium supplements in control and STZ-diabetic rats. CO-INVESTIGADOR
  • 2016-2018       DICYT  Síntesis, Propiedades Anti-inflamatorias y Estudios  Computacionales  de  Derivados de Chalconas como Inhibidores de 5- LOX (PRINCIPAL)
  • 2015-2019       FONDECYT REGULAR    Organometallic complexes linked to macrocycle    groups    by    a chromophore bridging ligand, as potential optical and electrochemical sensors  for  the  detection  of  metal ions. (CO-INVESTIGADOR)
  • 2012-2015        FONDEF            Generación   y   desarrollo   de   una vacuna recombinante eficaz contra el circovirus  porcino Tipo 2 potenciada con citoquinas inmuno-reguladoras: una solución biotecnológica para la porcicultura nacional (CO-INVESTIGADOR)
  • 2012-2015        FONDECYT REGULAR    NEW ISOFLAVANONES AND ISOFLAVANS DERIVATIVES AS LIPOXYGENASE INHIBITORS: COMPUTATIONAL STUDIES, SYNTHESIS AND BIOLOGICAL ASSAY (PRINCIPAL)
  • 2011-2013        DICYT  Cumarinas     7-o    preniladas     ¿Un modelo   interesante    de   fármacos antiinflamatorios? (CO-INVESTIGADOR)
  • 2010-2014        FONDECYT REGULAR    novel  solvato-  and halochromic betaines: synthesis, evaluation and development of theoretical models (COINVESTIGADOR)
  • 2010-2012        DICYT  Síntesis y  evaluación  biológica  de isoflavonoides  como  inhibidores  de 12   y   15-lipoxigenasa   humana,  a partir    de    un    diseño    in    silico. (PRINCIPAL)
  • 2008-2009        FONDECYT INICIACIÓN molecular   modelling   studies of enzyme-inhibitor interactions in human platelet lipoxygenases (PRINCIPAL)
  • 2007-2009        FONDECYT REGULAR    interacciones soluto-solvente de sondas solvatocromicas  en solucion (CO-INVESTIGADOR)
Últimas Publicaciones: 

Entre sus ultimas publicaciones, destacan :

  • 2020 Inhibition of soybean 15-lipoxygenase (15-sLOX) and human 5-lipoxygenase (5-hLOX) by extracts of leaves, stem bark, phenols and catechols isolated from Lithraea caustica (Anacardiaceae). Muñoz Ramírez, A. C., Mascayano, C*., Barriga, A., Echeverria, J., & Urzua, A.Frontiers in Pharmacology, 11, 1773. Impact Factor 4.225 Q1
  • 2020 Design, Synthesis and Biological Evaluation of Ferrocenyl Thiazole and Thiazolo[5,4- d]thiazole Catechols as Inhibitors of 5-hLOX and as Antibacterials against Staphylococcus aureus. Structural Relationship and Computational Studies. Erick Flores  Michelle Muñoz-Osses  Claudia Torrent  Yesseny Vásquez-Martínez  Alejandra Gómez  Marcelo Cortez-San Martin  Andrés Vega  Angel A. Martí  Fernando Godoy  Carolina Mascayano*Organometallics. Published on 01 Jan 2020. Impact Factor 2019: 3.804 Q1
  • 2020 Biological Properties and Absolute Configuration of Flavanones From Calceolariathyrsiflora Graham. Ernesto Valdés  César González  Katy Díaz  Yesseny Vásquez-Martínez  Carolina Mascayano*  Claudia Torrent  Francisco Cabezas  Sophia Mejias  Margarita Montoya  Marcelo Cortez-San Martín  Marcelo A. Muñoz  Pedro Joseph-Nathan  Mauricio Osorio  Lautaro Taborga. Frontiers in Pharmacology. Published on 28 Jul 2020. Impact Factor 4.225 Q1
  • 2020 Study of two isoforms of lipoxygenase by kinetic assays, docking and molecular dynamics of a specialised metabolite isolated from the aerial portion of Lithrea caustica (Anacardiaceae) and its synthetic analogs. Alejandra Muñoz-Ramírez, Claudia Torrent-Farías, Carolina Mascayano-Collado,* Alejandro Urzúa-Moll Phytochemistry Volume 174June 2020Article 112359 (IF 3.044 Q1)
  • 2020 Importance of the electrolyte cation on the non-covalent interactions in the electrooxidation of 1-heptanol on gold in 0.1 M alkali metal hydroxides. Ureta-Zañartu, M.S., Méndez-Torres, A.M., Fernández, F., (...), Mascayano, C., Gutiérrez, C. Materials Chemistry and Physics. 246,122828(IF 3.408 Q2)
  • 2020 A heterologous viral protein scaffold for chimeric antigen design: An example PCV2 virus vaccine candidate. Emilio Lamazares 1OrcID,Fernando Gutiérrez 1,Angela Hidalgo 1OrcID,Nicolas A. Gutiérrez 1,Felipe I. Espinoza 1,Oliberto Sánchez 1,Marcelo Cortez-San Martín 2,Carolina Mascayano 3,Javier González 4,José Saavedra 2,Claudia Altamirano 5OrcID,Manuel Mansur 6,Álvaro Ruiz 7,*OrcID andJorge R. Toledo 1,* Viruses 12(4),385 (IF 3.816 Q2)
  • 2019 Development of an Isavirus minigenome system to study the function of the pocket RNA binding domain of the viral nucleoprotein (NP) in salmon cells. Daniela Toro‐Ascuy, Alvaro Santibañez, Victor Peña, Carolina Beltran‐Pavez, Luis Cottet, Cristian Molina, Margarita Montoya, Nicolas Sandoval, Yesseny Vásquez‐Martínez, Carolina Mascayano, Marcelo Cortez‐San Martín. Journal of Fish Diseases (IF 2.318 Q1)
  • 2019 Antifungal and physicochemical properties of inclusion complexes based on -cyclodextrin and essential oil derivatives. Andrea Herrera1,2, Francisco J. Rodríguez1,2*, Julio E. Bruna1,2, Romina L. Abarca3, María J. Galotto1,2, Abel Guarda1,2, Carolina Mascayano4, Claudia Sandoval-Yáñez5, Marisa Padula6 and Fabiana Ramos Souza Felipe6. Food Research International (I.F. 4.972 Q1 0.84
  • 2019 ANTIBACTERIAL AND LIPOXIGENASE inhibitor activities of BENZYL PHENYL KETONES : Biological and computational studies. Giannina Toledo, Claudia Torrent, Francisco Cabezas, Victoria Espinosa, Yesseny Vásquez-Martínez, Margarita Montoya-K, Marcelo Cortez-San Martín, Silvia Sepúlveda-Boza & Carolina Mascayano* Bioorganic chemistry.(I.F. 4.831) Q1
  • 2019 Antimicrobial, Anti-inflammatory and Antioxidant Activities of Polyoxygenated Chalcones Yesseny A. Vásquez-Martínez, Mauricio E. Osorio*, Diego A. San Martín, Marcela A. Carvajal, Alejandra P. Vergara, Elizabeth Sanchez, Marcela Raimondi, Susana A. Zacchino, Carolina Mascayano, Claudia Torrent, Francisco Cabezas, Sophia Mejias, Margarita Montoya, Marcelo Cortez-San Martín Journal of the Brazilian Chemical Society,(I:F 1.399)Q3
  • 2018 Docking, Steered Molecular Dynamics and QSAR Studies as Strategies for Studying Isoflavonoids as 5-, 12- and 15-Lipoxygenase Inhibitors Francisco Cabezas, Carolina Mascayano* Journal of Biomolecular Structure and Dynamics I.F (3.310) Q2
  • 2018 Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance Andrea del Campo, Catalina Bustos, Claudio Acuña-Castillo, Carolina Mascayano, Leonel E Rojo. Frontiers inEndocrinology. I.F (3.644) Q2
  • 2017 Discovery two potent and new inhibitors of 15-lipoxygenase: (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one and (E)-O-(4-(((7-hydroxy-2-oxo-2H-chromen-3-yl)imino)methine) phenyl)dimethylcarbamothioate Nuñez, C., Morales, N., García-Beltran, O., Mascayano, C.*, & Fierro, A. (2017). Medicinal Chemistry Research, 1-11. 2707–2717  I.F (1.783) Q4 2.07
  • 2017 Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase Bioorganic & Medicinal Chemistry Letters Wiliams Acevedo-Fuentes; Pablo Dahech; Claudia Torrent; Pablo Barrias; Macarena Rojas; Carolina Mascayano and Cristian Tirapegui. 1649-1653 I.F (2.572) Q2 1.03
  • 2017 Study of Specific Interactions in Inclusion Complexes of Amine-Terminated PAMAM Dendrimer/Flavonoids by Experimental and Computational Methods. International Journal of Polymeric Materials and Polymeric Biomaterials, Vergara-Jaque, A., Comer, J., Sepúlveda-Boza, S., Santos, L. S., Mascayano, C*., & Sandova-Yáñez, C*.485-494 I.F (2.127) Q3 1.82
  • 2016 Structural Analysis and Molecular Docking of   Trypanocidal   Aryloxy-quinones in Trypanothione and Glutathione Reductases: A Comparison with Biochemical Data., Journal of Biomolecular Structure and Dynamics Vera, B., Vázquez, K., Mascayano, C., Tapia, R. A., Espinosa, V., Soto-Delgado, J., ... & Paulino, M. I.F (3,107) Q2 1.27
  • 2015 Dyp-Type  Peroxidase  (DypA)  from  the Bioleaching  Acidophilic Bacterium Leptospirillum Ferriphilum DSM 14647 Advanced Materials Research Journal, en prensa Mackarena Contreras, Carolina Mascayano, Renato Chávez,   Alonso Ferrer, Braulio Paillavil and Gloria Levicán*
  • 2015 On  the  dramatic  increase  with  chain length   of   the   oxidazability  of   linear saturated  aliphatic  alcohols  on  gold  in alkaline Electrochimica Acta Volume 165, 20 May
  • 2015, Pages 232–238 M.Soledad Ureta-Zañartu, Carolina Mascayano, Claudio Gutiérrez I.F (5.116) Q1 1.05 2015 Development   of   A   Reverse   Genetic System for Infectious Salmon Anemia Virus (ISAV): Rescue of Recombinant Fluorescence Virus Using Salmon ITS-1 Region as a Novel Promoter Applied and Enviromental  Microbiology Daniela Toro-Ascuy, Carolina Tambley, Carolina Beltran, Carolina Mascayano, Nicolas Sandoval, Eduardo Olivares, Rafael A. Medina, Eugenio Spencer, and Marcelo Cortez-San Martín  I.F (3.633) Q2 0.85