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Dr. Carolina Mascayano

E-mail: 
carolina.mascayano@usach.cl

Biography: 
PhD Carolina Mascayano, studied in 2000 to obtain the Bachelor of Chemistry degree from the Universidad de Santiago de Chile.
Later she obtained her doctorate degree in 2006 from the same university.
Research Area: 

Her research area is focused on computational and medical Chemistry.

 

Projects: 
Her latest projects include:
  • 2010-2012 DICYT Synthesis and biological evaluation of isoflavonoids as inhibitors of human 12 and 15-lipoxygenase, from an in silico design. (Researcher Principal)
  • 2011-2013 DICYT 7-o preylated coumarins An interesting model of anti-inflammatory drugs? (CO-Researcher)
  • 2020-2024 FONDECYT REGULAR SEARCH OF NEW PHARMACOPHORES FOR DUAL 5-LOX AND COX-2 INHIBITORS BASED ON CATECHOLIC ISOFLAVAN AND BENZYLPHENYLKETONE DERIVATIVES: BIOLOGICAL AND IN SILICO COMPLEMENTARY APPROACHES (principal Researcher)
  • 2016-2018 DICYT Synthesis, Anti-inflammatory Properties and Computational Studies of Chalcone Derivatives as 5-LOX Inhibitors (Principal Researcher)
  • 2012-2015 FONDECYT REGULAR NEW ISOFLAVANONES AND ISOFLAVANS DERIVATIVES AS LIPOXYGENASE INHIBITORS: COMPUTATIONAL STUDIES, SYNTHESIS AND BIOLOGICAL ASSAY ( Principal Researcher)
  • 2007-2009 FONDECYT REGULAR SOLUTO-SOLVENT INTERACTIONS OF SOLVATCHROMIC PROBES IN SOLUTION (CO-Researcher)
  • 2010-2014 FONDECYT REGULAR NOVEL SOLVATO- AND HALOCHROMIC BETAINES: SYNTHESIS, EVALUATION AND DEVELOPMENT OF THEORETICAL MODELS (Co-Researcher)
  • 2008-2009 FONDECYT INICIACIÓN MOLECULAR MODELLING STUDIES OF ENZYME-INHIBITOR INTERACTIONS IN HUMAN PLATELET LIPOXYGENASES (Principal Researcher)
  • 2012-2015 FONDEF Generation and development of an effective recombinant vaccine against type 2 porcine circovirus enhanced with immunoregulatory cytokines: a biotechnological solution for national pig farming (CO- Researcher)
  • 2015-2019 FONDECYT REGULAR Organometallic complexes linked to macrocycle groups by a chromophore bridging ligand, as potential optical and electrochemical sensors for the detection of metal ions. (CO- Researcher)
  • 2017-2020 FONDECYT REGULAR Enhancement of endothelium signaling by dietary polyphenols and potassium supplements in control and STZ-diabetic rats. (CO- Researcher)
  • 2019-2022 FONDECYT REGULAR Organometallic complexes linked to macrocycle groups by a chelating bridging ligand, as potential water-soluble or immobilized sensors for the detection of metal ions (CO- Researcher)
  • 2019-2021 DICYT Search for New Pharmacophores based on the structure of benzylphenylketones as possible dual inhibitors of COX-2/5-hLOX: In-silico and Biological Studies.
 
Latest Publications: 
  • 2020 Inhibition of soybean 15-lipoxygenase (15-sLOX) and human 5-lipoxygenase (5-hLOX) by extracts of leaves, stem bark, phenols and catechols isolated from Lithraea caustica (Anacardiaceae). Muñoz Ramírez, A. C., Mascayano, C*., Barriga, A., Echeverria, J., & Urzua, A. Frontiers in Pharmacology, 11, 1773. Impact Factor 4.225 Q1
  • 2020 Design, Synthesis and Biological Evaluation of Ferrocenyl Thiazole and Thiazolo[5,4- d]thiazole Catechols as Inhibitors of 5-hLOX and as Antibacterials against Staphylococcus aureus. Structural Relationship and Computational Studies. Erick Flores  Michelle Muñoz-Osses  Claudia Torrent  Yesseny Vásquez-Martínez  Alejandra Gómez  Marcelo Cortez-San Martin  Andrés Vega  Angel A. Martí  Fernando Godoy  Carolina Mascayano* Organometallics. Published on 01 Jan 2020 Impact Factor 2019: 3.804 Q1
  • 2020 Biological Properties and Absolute Configuration of Flavanones From Calceolariathyrsiflora Graham. Ernesto Valdés  César González  Katy Díaz  Yesseny Vásquez-Martínez  Carolina Mascayano*  Claudia Torrent  Francisco Cabezas  Sophia Mejias  Margarita Montoya  Marcelo Cortez-San Martín  Marcelo A. Muñoz  Pedro Joseph-Nathan  Mauricio Osorio  Lautaro Taborga. Frontiers in Pharmacology. Published on 28 Jul 2020 Impact Factor 4.225 Q1
  • 2020 Study of two isoforms of lipoxygenase by kinetic assays, docking and molecular dynamics of a specialised metabolite isolated from the aerial portion of Lithrea caustica (Anacardiaceae) and its synthetic analogs. Alejandra Muñoz-Ramírez, Claudia Torrent-Farías, Carolina Mascayano-Collado,* Alejandro Urzúa-Moll. Phytochemistry Volume 174June 2020Article 112359 (IF 3.044 Q1)
  • 2020 Importance of the electrolyte cation on the non-covalent interactions in the electrooxidation of 1-heptanol on gold in 0.1 M alkali metal hydroxides Ureta-Zañartu, M.S., Méndez-Torres, A.M., Fernández, F., (...), Mascayano, C., Gutiérrez, C. Materials Chemistry and Physics 246,122828(IF 3.408 Q2) . 
  • 2020 A heterologous viral protein scaffold for chimeric antigen design: An example PCV2 virus vaccine candidate Emilio Lamazares 1OrcID,Fernando Gutiérrez 1,Angela Hidalgo 1OrcID,Nicolas A. Gutiérrez 1,Felipe I. Espinoza 1,Oliberto Sánchez 1,Marcelo Cortez-San Martín 2,Carolina Mascayano 3,Javier González 4,José Saavedra 2,Claudia Altamirano 5OrcID,Manuel Mansur 6,Álvaro Ruiz 7,*OrcID andJorge R. Toledo 1,* Viruses 12(4),385 (IF 3.816 Q2)
  • 2019 Development of an Isavirus minigenome system to study the function of the pocket RNA binding domain of the viral nucleoprotein (NP) in salmon cells Daniela Toro‐Ascuy, Alvaro Santibañez, Victor Peña, Carolina Beltran‐Pavez, Luis Cottet, Cristian Molina, Margarita Montoya, Nicolas Sandoval, Yesseny Vásquez‐Martínez, Carolina Mascayano, Marcelo Cortez‐San Martín Journal of Fish Diseases (IF 2.318 Q1)
  • 2019 Antifungal and physicochemical properties of inclusion complexes based on -cyclodextrin and essential oil derivatives Andrea Herrera1,2, Francisco J. Rodríguez1,2*, Julio E. Bruna1,2, Romina L. Abarca3, María J. Galotto1,2, Abel Guarda1,2, Carolina Mascayano4, Claudia Sandoval-Yáñez5, Marisa Padula6 and Fabiana Ramos Souza Felipe6 Food Research International (I.F. 4.972 Q1) 0.84
  • 2019 ANTIBACTERIAL AND LIPOXIGENASE inhibitor activities of BENZYL PHENYL KETONES : Biological and computational studies. Giannina Toledo, Claudia Torrent, Francisco Cabezas, Victoria Espinosa, Yesseny Vásquez-Martínez, Margarita Montoya-K, Marcelo Cortez-San Martín, Silvia Sepúlveda-Boza & Carolina Mascayano* Bioorganic chemistry.(I.F. 4.831) Q1
  • 2019 Antimicrobial, Anti-inflammatory and Antioxidant Activities of Polyoxygenated Chalcones Yesseny A. Vásquez-Martínez, Mauricio E. Osorio*, Diego A. San Martín, Marcela A. Carvajal, Alejandra P. Vergara, Elizabeth Sanchez, Marcela Raimondi, Susana A. Zacchino, Carolina Mascayano, Claudia Torrent, Francisco Cabezas, Sophia Mejias, Margarita Montoya, Marcelo Cortez-San Martín Journal of the Brazilian Chemical Society,(I:F 1.399)Q3
  • 2018 Docking, Steered Molecular Dynamics and QSAR Studies as Strategies for Studying Isoflavonoids as 5-, 12- and 15-Lipoxygenase Inhibitors Francisco Cabezas, Carolina Mascayano* Journal of Biomolecular Structure and Dynamics I.F (3.310) Q2
  • 2018 Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance Andrea del Campo, Catalina Bustos, Claudio Acuña-Castillo, Carolina Mascayano, Leonel E Rojo. Frontiers inEndocrinology. I.F (3.644) Q2
  • 2018 A Theoretical Assessment of Antioxidant Capacity of Flavonoids by means of Local Hyper-Softness Sandoval-Yañez, C., Mascayano, C.*, & Martínez-Araya, J. I. (2017). A theoretical assessment of antioxidant capacity of flavonoids by means of local hyper–softness. Arabian Journal of Chemistry. I.F (4.762) Q2
  • 2017 Discovery two potent and new inhibitors of 15-lipoxygenase: (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one and (E)-O-(4-(((7-hydroxy-2-oxo-2H-chromen-3-yl)imino)methine) phenyl)dimethylcarbamothioate Nuñez, C., Morales, N., García-Beltran, O., Mascayano, C.*, & Fierro, A. (2017). Medicinal Chemistry Research, 1-11. 2707–2717  I.F (1.783) Q4 2.07
  • 2017 Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase Bioorganic & Medicinal Chemistry Letters Wiliams Acevedo-Fuentes; Pablo Dahech; Claudia Torrent; Pablo Barrias; Macarena Rojas; Carolina Mascayano and Cristian Tirapegui. 1649-1653 I.F (2.572) Q2 1.03
  • 2017 Study of Specific Interactions in Inclusion Complexes of Amine-Terminated PAMAM Dendrimer/Flavonoids by Experimental and Computational Methods. International Journal of Polymeric Materials and Polymeric Biomaterials, Vergara-Jaque, A., Comer, J., Sepúlveda-Boza, S., Santos, L. S., Mascayano, C*., & Sandova-Yáñez, C*.485-494 I.F (2.127) Q3 1.82
  • 2016 Structural Analysis and Molecular Docking of   Trypanocidal   Aryloxy-quinones   in Trypanothione        and        Glutathione Reductases:     A     Comparison     with Biochemical Data., Journal of Biomolecular Structure and Dynamics Vera, B., Vázquez, K., Mascayano, C., Tapia, R. A., Espinosa, V., Soto-Delgado, J., ... & Paulino, M. I.F (3,107) Q2 1.27
  • 2015 Dyp-Type  Peroxidase  (DypA)  from  the Bioleaching  Acidophilic Bacterium Leptospirillum Ferriphilum DSM 14647 Advanced Materials Research Journal, en prensa Mackarena  Contreras, Carolina Mascayano, Renato Chávez, Alonso Ferrer, Braulio Paillavil and Gloria Levicán*
  • 2015 On  the  dramatic  increase  with  chain length   of   the   oxidazability  of   linear saturated  aliphatic  alcohols  on  gold  in alkaline Electrochimica Acta Volume 165, 20 May
  • 2015, Pages 232–238 M.Soledad     Ureta-Zañartu,    Carolina Mascayano, Claudio Gutiérrez I.F (5.116) Q1 1.05 2015 Development   of   A   Reverse   Genetic System for Infectious Salmon Anemia Virus (ISAV): Rescue of Recombinant Fluorescence Virus Using Salmon ITS-1 Region as a Novel Promoter Applied and Enviromental  Microbiology Daniela Toro-Ascuy, Carolina Tambley, Carolina Beltran, Carolina Mascayano, Nicolas Sandoval, Eduardo Olivares, Rafael A. Medina, Eugenio Spencer, and Marcelo Cortez-San Martín  I.F (3.633) Q2 0.85